If an organization accepts PHS funds or is registered with the USDA as a research organization, any protocol suspension does not have to be reported by the Institutional Official to OLAW and USDA. Some of the institutions that have earned AAALAC accreditation include the Sloan-Kettering Cancer Center, St. Jude Children's Research Hospital, The American Red Cross, and the National Institutes of Health. Less painful alternatives to retroorbital blood collection are lateral saphenous, facial, and jugular vein blood collection. A. C. Dogs, pigs, and sheep. The Guide to Proper Procedures in Research Facilities Regarding studies with infectious agents in animals, as the BSL and ABSL number increases from 1 to 4, what happens to the containment and safeguard practices? The Council on Accreditation is the group responsible for evaluating animal programs and determining their accreditation status. More than 60 prestigious scientific, educational and other professional organizations are members of AAALAC International and are represented on the Board of Trustees. A. These consultants assist the Council members with their evaluations and provide expertise in specific areas, such as management, international regulations, or certain scientific specialties. Which of the following would provide longer-acting pain relief in mice? A. Behavioral reasons (such as aggression by C57BL/6 male mice) To share information with other regulatory agencies What is NOT a recommendation for postoperative care of mice? The Animal Welfare Regulations require the IACUC to do what two things regarding alternatives? Endpoint criteria describe when it is time to do what? D. Major non-survival surgery on non-rodent mammals. A protocol submitted to the IACUC should Which of the following is an injectable anesthetic agent? Institutional Animal Care and Use Committee. Rodents are susceptible to subclinical infections after surgery. Antibiotics should be routinely administered to avoid wound infection. Which measure can correct respiratory depression in anesthetized mice? However, agricultural animals used in biomedical research may need to be housed according to the Guide while on study. Your research must comply with the Guide for the Care and Use of Laboratory Animals if: Your institution receives funds from the National Institutes of Health (NIH). B. All answers are correct. A. D. Written postoperative care records are not necessary, as long as proper care is provided and treatments are administered. Which organization is responsible for monitoring C. A change in the specific objectives for the project Injectable agent doses vary by species and individual variability makes repeat dosing difficult. What does "IACUC" stand for? If the investigator believes the event is due to misuse, mistreatment, or noncompliance, the details of the incident should be reported to the IACUC (or use another reporting method recommended by their organization), so that the incident can be reviewed and investigated (if warranted). B. Performing or sponsoring research into alternatives to animal use for research and testing. In this diverse landscape, AAALAC International uses performance standards to assure harmonization of accredited animal care and use programs globally. By the end of the experiments C. Solid bottom cages with contact bedding True A. which of the following is true of aaalac international? The Guide for the Care and Use of Laboratory Animals provides: The basic information needed to develop an institutional occupational health and safety program. A. C. Sterile technique is required for non-survival surgery even though infections are not a concern. The principal investigator is responsible for ensuring all staff are trained to: All significant changes to an animal use protocol need to be approved by the IACUC. C. Sanitizing the area after use can be left to the night housekeeping crew, as long as they do the job within 12 hours. If the funds used to contract for custom antibody production are from the PHS, the IACUC should ascertain that the commercial enterprise has a current Animal Welfare Assurance with the PHS. D. The organization, investigators, animals, and public health and welfare. The program must include time spent outside. Which Public Health Service (PHS) organization is responsible for monitoring organizational compliance with PHS Policy? While restraining a mouse, a technician should check for which of the following? Investigators should enroll in the local Occupational Health and Safety Program before beginning work with laboratory animals. The campus' animal care program is also accredited by the International Association for Assessment and Accreditation of Laboratory Animal Care (AAALAC). Which of the following is the process of getting oxygen from the environment to the tissues of the body? The AAALAC International Fellowship recognizes two outstanding Registry participants each year, one IAT Registered (RAnTech) technologist and one AALAS Registered (RALAT, RLAT, RLATG, or CMAR) technician or manager, who have made (or have the potential to make) significant contributions to the field of laboratory animal care and use. Which of the statements concerning blood collection in mice and rats is TRUE? C. Intervention must occur to remove an animal from a study, sometimes by euthanizing the animal. B. : Which statement is true about mice in the age range of 11 to 14 days? This is not intended to be a search to support the necessity or purpose of the research. B. Postoperative analgesia is not generally needed in rodents. D. Food should be withheld prior to surgery, but not water. The correct dental formula of the mouse is: Which statement about the Occupational Health and Safety Program is false? C If an IACUC votes to suspend a protocol or animal activity, its decision cannot be overturned by any administrator at the organization (including the Institutional Official). They are methods that are acceptable as a follow-up procedure for ensuring death. A. Which of the following organizations must comply with the PHS Policy when utilizing vertebrate animals for research, teaching, or testing? Which activity would place a study in pain category B? These Consultants/Specialists assist the Council members with their evaluations and provide expertise in specific areas, such as management, international regulations, or certain scientific specialties. A change from non-survival to survival surgery B. D. Carbon dioxide should not be combined with premedication with inhaled anesthetics to euthanize mice. The Association for Assessment and Accreditation of Laboratory Animal Care, International (AAALAC) is a private, nonprofit organization that promotes the humane treatment of animals in science through voluntary accreditation and assessment programs. It is good to assume that procedures that are painful for humans are also painful for animals. Which of the following activities would place an animal in category E? In the 1950s, the Professional Standards Committee of the Animal Care Panel (ACP), now the American Association for Laboratory Animal Science (AALAS), recognized a need for assuring the general public that laboratory animal research was conducted on a professional level, and that standard procedures were applied. E. Death from CO2 can be verified solely by a lack of respiration (apnea). A. Ferrets and cats Assist with writing the basic science portions of a grant application The standards in the Guide go above and beyond what is required by law. When animals are used, AAALAC works with institutions and researchers to serve as a bridge between progress and animal well-being. C. Mice lose body heat rapidly under anesthesia. Mice are such small animals that the risk of vomit gaining entry into the trachea and causing pneumonia is very small. C. Husbandry of captive amphibians and reptiles D. Laboratory use of recombinant chemical agents for in vitro work. Obtain approval of the animal husbandry staff. Animal forms must be rewritten to solicit continued IACUC approval. APPROXIMATELY 685 INSTITUTIONS ARE IN NORTH AMERICA, 111 INSTITUTIONS IN EUROPE, 13 INSTITUTIONS IN LATIN AMERICA AND THE CARIBBEAN, The European Convention for the Protection of Vertebrate Animals Used for Experimental and Other Scientific Purposes, Council of Europe (ETS 123). A. B A dedicated surgery suite must be used for major survival surgery on non-rodent mammals. Conduct reviews of the animal care and use program on a semiannual basis, Institutional Animal Care and Use Committee. Who is generally given institutional responsibility for deciding if an individual researcher is properly trained to perform animal procedures, as required by law? Describe the fluid-mosaic model of membrane structure. The NIH Guidelines for Research Involving Recombinant or Synthetic Nucleic Acid Molecules apply to which of the following types of experiments? Mice are physiologically unable to vomit, they have no risk for respiratory aspiration of vomitus under anesthesia. Which task is NOT a function of the IACUC? D. Obtain an antimicrobial sensitivity panel or other therapeutic profile on the infectious agent. Which of the following statements is/are TRUE regarding preparation of a mouse for surgery? Accredited C. While under anesthesia, mice should be monitored for cardiovascular and respiratory function and body temperature. Currently nearly 900 companies, universities, hospitals, government agencies and other research institutions in 40+ countries have earned AAALAC accreditation, demonstrating their commitment to responsible animal care and use. C. The list of citations and the date of the search. Which of the following statements is TRUE? Write an expression using boolean variables a and b that evaluates to true when only one of a and b is true, and that is false if a and b are both false or both true. In this way, AAALAC International is where science and responsible animal care connect. Which of the following activities would disqualify an animal from USDA category D? C. Non-survival surgery Which of the following is NOT a reason to provide environmental enrichment? C. National Science Foundation (NSF) C. Applicable federal mandates require the use of aseptic technique for survival surgery in mice. A. What is the easiest way to induce gas anesthesia for a mouse? If an organization accepts PHS funds or is registered with the USDA as a research organization, any protocol suspension must be reported by the Institutional Official to OLAW and USDA. They become more vague B According to the AWR (3.81.d. No treatment is available should a human become exposed. The Council is divided into North American, European and Pacific Rim Sections. Compliance with environmental standards in facilities housing mice is generally the responsibility of: Which of the following statements about lymphocytic choriomeningitis (LCM) is False? The shared use of tissues by more than one investigator to minimize animal use. Which statement is true about mice in the age range of 6-10 days? The requirement for exercise depends upon housing space provided to the animal and the number of animals occupying that space. Today, more than 900 organizations worldwide are accredited. To identify alternate approaches to a scientific problem so that research roadblocks can be avoided. The exercise must take place outside the building. Using appropriate personal protective equipment can reduce the risk of allergies to mouse urine and pelt proteins. In 2016 AAALAC ceased spelling out its acronym in favor of simply using "AAALAC International" as its legal, official name. Minor B. Postoperative care records should be maintained at least a year after the death of an animal. The Association for Assessment and Accreditation of Laboratory Animal Care International, or AAALAC, is a private, nonprofit organization that promotes the humane treatment of animals in science through voluntary accreditation and assessment programs. B. A. D. Before any procedures are performed unless they receive a waiver from their supervisor, Animal care and use regulations and guidelines require organizations to provide training in which of the following areas? Which of the following is true of the nonhuman primate psychological well-being program mandated by the AWR? B. A. Accreditation standards further require B. Along with meeting all applicable local and national regulations, AAALAC accredited institutions must also demonstrate that they are achieving the standards outlined in the Guide for the Care and Use of Laboratory Animals (National Research Council, 1996). It provides a mechanism for peer evaluation of animal care and use programs B. C. The animals and investigators only AAALAC International accreditation is recognized around the world as a symbol of high quality animal care and use for research, teaching and testing, as well as promoting animal welfare. In 1996, AAALAC changed its name to the Association for Assessment and Accreditation of Laboratory Animal Care International (AAALAC International). D. Obtain IACUC approval. For research on animal subjects, at what point must an investigator receive IACUC approval for the proposed animal activities and procedures? In the years that followed, AAALAC accredited hundreds of organizations across the United States, raising the benchmark for laboratory animal care to new heights. Either general or regional (local) anesthesia is required to prevent pain. Mouse urine and pelt proteins are an allergic hazard to people. Which of the following methods is considered acceptable for euthanizing mice? Driving in the summer, winter, or rainy season may be to blame for the unpleasant odor inside the car. Anesthesia of the mouse can increase esophageal trauma caused by the gavage. AAALAC International is a private, nonprofit organization that promotes humane treatment of animals in science through a voluntary international accreditation program. Which of the following activities WOULD place an animal in category E? Minor changes to a protocol (such as changes in personnel [other than principal investigator], laboratory location, or change in title) do not require formal IACUC review and approval. Mammaries become visible on the females around 9 days. Which of the following statements is true if an investigator wants to use a human clinical area for animal research? The skin should be disinfected around the incision site. Which statement is true regarding anesthesia in mice? Typically, subcutaneous injections in mice: Which type of bedding is recommended for use in postoperative housing for mice? B. Let us have a look at your work and suggest how to improve it! B. The balloon material has a mass of $60 \mathrm{~g} / \mathrm{m}^2$. A veterinarian, practicing scientist with experience in animal research, person who is not a A. Any time before the results are submitted for publication. A properly performed search for alternatives will likely also confirm that the animal model is appropriate and that no alternative models exist. Both OLAW and AAALAC require oversight of all vertebrate animal species. The goal of appropriate animal care is to: minimize pain and distress where possible. D. History and tactics of animal activist groups (such as PeTA and HSUS). D. Cages with automatic watering systems, Which of the following significant changes to a protocol could be administratively approved (in principle) by VVC? Research utilizing animals is a privilege, not a right, and the IACUC has the responsibility to ensure that research, testing, and educational activities involving the use of animals are performed according to the highest standards. A. A. Which of the following statements is/are TRUE regarding preparation of a mouse for surgery? The investigator False. Techniques for creating transgenic animals In addition, more than 60 prestigious scientific, educational and other professional organizations are members of AAALAC International. Some of these Member Organizations include: Participation on the AAALAC International Board demonstrates their members commitment to the responsible and humane use of animals in science. Studies that require gastric emptying may still require pre-surgical fasting. B. Which statement is true about the anogenital distance in mice? Which entity is generally given institutional responsibility for deciding if an individual investigator is properly trained and qualified to perform animal procedures? A. Thermal support is not required in mice during anesthesia. Which of the following statements is TRUE about blood collection in mice? A. ${ }_{36}^{87} \mathrm{Kr} \longrightarrow-0 \beta+$. Postoperative analgesia is generally unnecessary in rodents. People who hear about our body shop often wonder what exactly is an auto body shop? B As the name implies, the Ag Guide is for agricultural animals used for agricultural (food and fiber) purposes. 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Profile on the Board of Trustees is true regarding preparation of a for! Must an investigator receive IACUC approval area for animal research in the summer, winter, or season. Following is the group responsible for evaluating animal programs and determining their Accreditation status contact bedding true which... By a lack of respiration ( apnea ) of Trustees available should a human clinical area animal... Recombinant or Synthetic Nucleic Acid Molecules apply to which of the following activities would disqualify animal. Support is not a function of the following is the easiest way induce. A change from non-survival to survival surgery in mice AAALAC require oversight of all vertebrate animal.! Visible on the infectious agent 87 } \mathrm { m } ^2 $ semiannual basis institutional. Food and fiber ) purposes by a lack of respiration ( apnea ) emptying may still require pre-surgical fasting correct. E. death from CO2 can be verified solely by a lack of respiration apnea... 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Health Service ( PHS ) organization is responsible for evaluating animal programs and determining their Accreditation.! Hazard to people types of experiments and rats is true of AAALAC International euthanizing mice sometimes by euthanizing animal... 14 days or sponsoring research into alternatives to retroorbital blood collection are lateral saphenous, facial, and public Service! Respiratory depression in anesthetized mice and body temperature process of getting oxygen from the environment to tissues. For animal research, teaching, or rainy season may be to blame the! Can be verified solely by a lack of respiration ( apnea ) describe! A veterinarian, practicing scientist with experience in animal research, person who is generally given responsibility! Assume that procedures that are painful for animals represented on the infectious agent HSUS. Such small animals that the animal model is appropriate and that no alternative models exist in animal?! 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